Amazing Spider-man #678 Variant is probably the most famous, and costly, depiction of Mary Jane as Venom. The book has the earliest cover appearance of Mary Jane as Venom. There have been several more popular covers of Mary Jane as Venom. But what is the first appearance of Mary Jane as Venom?
The first appearance of a female Venom was in a cameo in Venom Sinner Takes All #2, with her first full appearance in Venom Sinner Takes All #3. This one was Eddie Brock’s ex-wife Ann Weying. But this was not Mary Jane in the Venom Symbiote.
Mary Jane became Venom in the comic Amazing Spider-man Renew Your Vows #8. In addition to the regular cover, there was a Incentive Clayton Crain cover. The book was released in August of 2017. This was not her first cover appearance as Venom in the series. The honor goes to a series of Renew Your Vow #1 Unknown Comics variantss done by Mike Perkins. There were three versions of it, a Purple Variant limited to 3,000 copies, a Black and White Variant, limited to 1,500 copies, and an Orange Variant, limited to 500 copies. These variants (seen below) were released in January 2017.
In between the January and August release dates if Amazing Spider-man #1 and #8, another Mary Jane Venom was released. This time it was the Venom #151 Francesco Mattina variant. This cover was released in June of 2017 and sold fairly well. It was part of a larger Venomized variant run, just like the original Amazing Spider-man #678 Variant.
And also in (June) 2017 Amazing Spiderman #29 had a Mattina Comicxposure variant set. Four versions of Mary Jane as Venom were released. Two versions of the trade dress cover and two virgin variants were released.
The previous run of Amazing Spider-Man Renew Your Vows, the 2015 series, had a three cover Venomized Mary Jane set for Renew Your Vow #3. It was available in a regular Color Variant, a Black and White Variant, a Negative Variant, and a Red Variant. These came out around October 2015.
Finally, the Amazing Spider-man #678 Variant we mentioned before came out in January of 2012, pre-dating most of the other covers (and actual appearances) by several years. (There is also a later printed La Mole Convention Variant of this cover.)
So what was the first appearance of Mary Jane in the Venom Symbiote?
That honor goes to Spider-Man Power Pack #3 and #4. In this all ages book, a fashion designer gets a hold of the Venom Symbiote and sews it into three dresses. One of them modeled by Mary Jane Watson. When the symbiote hears Peter’s name, it turns the three runway models, Mary Jane included, into Venoms. These books were releases in March and April 2007. Unless I am missing a book, these would be the earliest appearances of Mary Jane as Venom.