Casting has began and is underway on the Disney+ She-Hulk project.
Casting is confirmed that Marvel is open to any ethnicity for the role, 25-34 y.o., with comedy experience a plus. Sources have also confirmed that Bruce Banner/Hulk will be in the show. There were mentions that She-Hulk will also become part of the Avengers in the future but at which point remains to be seen.
With the show in such early development, its hard to speculate on which villains could be included in the show. Its possible that the writers follow the original story and make the first season revolve around the Mobsters. But another possibility could be her long standing rivalry with Titania. Either way it will be interesting to see how it comes together.
She-Hulk joined the Avengers in Issue #221
She-Hulk joined the Fantastic Four in Issue #265